Research Topics

Nucleosides: Synthesis and Application

• Synthesis of base-modified nucleosides (azapurine and deazapurine nucleosides) mimicking the shape of canonical DNA or RNA constituents


• Synthesis of heterocycles related to canonical nucleobases including halogenated derivatives


• Synthesis of carbohydrates, including fluoro sugars, L-sugars and other modified sugar derivatives


• Development of stereoselective glycosylation techniques


• Synthesis of fluorescent nucleosides or nucleosides carrying reporter groups


• Development of nucleosides showing antiviral or anticancer activity

• Harmonization of the dA-dT vs the dG-dC base pair stability


• Parallel DNA and RNA


• Synthesis of base-modified and sugar-modified oligoribonucleotides and oligodeoxyribonucleotides


• Recognition studies on oligonucleotide duplexes and hairpins


• Formation of triplexes and quadruplexes containing modified nucleosides


• Oligonucleotides containing universal bases


• Oligonucleotide fluorescence and fluorescence quenching

• Synthesis of “soft” nanomaterials derived from DNA or RNA constructs


• Nucleic acid gold conjugates for sensitive DNA detection or for application in material science

• DNA Chips with optimal hybridization properties


• DNA Chips using parallel hybridization