Patents

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1.	Purine analog nucleoside and nucleotide compounds. Seela, Frank; Bourgeouis, Werner; Gumbiowski, Rainer; Röling, Angelika; Rosemeyer, Helmut; Mertens, Alfred; Zilch, Harald; König, Bernhard; Koch, Edith. (Boehringer Mannheim GmbH, Mannheim, Germany), US-Patent 5,446,139 1995.
2.	Desazapurin-Nucleosid-Derivate, Verfahren zu deren Herstellung sowie deren Verwendung bei der Nucleinsäure-Sequenzierung sowie als antivirale Mittel Seela, F.; Muth, H.-P.; Kaiser, K.; Bourgeois, W.; Mühlegger, K.; von der Eltz, H.; Batz, H.-G. (Boehringer Mannheim GmbH, Mannheim, Germany), EU-Patent 0 286 028 B1 1995.
3.	Nucleosid-Derivate und deren Verwendung als Arzneimittel Seela, F.; Bourgeois, W.; Gumbiowski, R.; Roeling, A.; Rosemeyer, H.; Mertens, A.; Zilch, H.; König, B.; Koch, E. (Boehringer Mannheim GmbH, Mannheim, Germany), EU-Patent 0 666 269 A2 1995.
4.	7-Deaza-2’-deoxyguanosine nucleotides and nucleic acids analogs thereof Seela, F. (Boehringer Mannheim GmbH, Mannheim, Germany), US-Patent 5,480,980 1996.
5.	Modified oligonucleotides, their preparation and their use. Seela, Frank; Thomas, Horst. (Hoechst Aktiengesellschaft, Germany), US-Patent 5,844,106 1998.
6.	Nucleotide monomers containing 8-azapurin bases or a derivative thereof, their preparation and their use in making modified oligonucleotides Seela, F, Lampe S. (Hoechst AG, Frankfurt, Germany), US-Patent 5,789,562 1998.
7.	Synthesis of 7-deaza-2’deoxyguanosine nucleotides Seela, F. (Roche Diagnostics GmbH, Mannheim, Germany), US-Patent 5,990,303 1999.
8.	Modified oligonucleotides, their preparation and their use Seela, F.; Lampe, S. (Hoechst AG, Frankfurt, Germany), US-Patent 6,066,720 2000.
9.	Modified oligonucleotides, their preparation and their use Seela, Frank; Thomas, Horst (Aventis Pharma Deutschland GmbH, Frankfurt am Main, Germany), US-Patent 6,150,510 2000.
10.	Desazapurine-nucleotide derivatives, processes for the preparation thereof, pharmaceutical compositions containing them and the use thereof for nucleic acid sequencing and as antiviral agents. Seela, Frank; Muth, Heinz-Peter; Kaiser, Klaus; Bourgeois, Werner; Mühlegger, Klaus, von der Eltz, Herbert, Batz, Hans-Georg. (Roche Diagnostics GmbH, Mannheim, Germany), US-Patent 6,211,158 B1 2001.
11.	N8- and C8-Linked purine bases as universal nucleosides used for oligonucleotide hybridization Seela, F.; Debelak, H.; Bergmann, F.; Heindl, D.; von der Eltz, H. (Roche Molecular Systems, Inc, Alameda, CA (US))..
12.	N8- and C8-Linked purine bases and structurally related heterocycles as universal nucleosides used for oligonucleotide hybridization Seela, F.; Debelak, H.; Bergmann, F.; Heindl, D.; von der Eltz, H. (Roche Diagnostics GmbH, Mannheim, Germany)..
13.	C-Nucleoside derivatives and their use in the detection of nucleic acids Mühlegger, K.; von der Eltz, H.; Seela, F.; Rosemeyer, H. (Roche Diagnostics GmbH, Mannheim, Germany), US-Patent 6,320,035 B1 2001.
14.	Desazapurine-nucleotide derivatives, processes for the preparation thereof, pharmaceutical compositions containing them and the use thereof for nucleic acid sequencing and as antiviral agents Seela, F.; Muth, H.-P.; Kaiser, K.; Bourgeois, W, Mühlegger, K.; von der Eltz, H.; Batz, H.-G. (Roche Diagnostics GmbH, Mannheim, Germany), US-Patent 6,211,158 B1 2001.
15.	Oligo-2’-deoxynucleotides and their use as pharmaceutical agents with antiviral activity Mühlegger, K.; von der Eltz, H.; Seela, F.; Rosemeyer, H. (Roche Diagnostics GmbH, Mannheim, Germany), US-Patent 6,329,346 B1 2001.
16.	2-Deoxyisoguanosines isosteric analogues and isoguanosine derivatives as well as their synthesis Seela, F.; Kasimierczuk, Z.; Mühlegger, K.; von der Eltz, H. (Roche Diagnostics GmbH, Mannheim, Germany), US-Patent 6,498,241 B1 2002.
17.	High density labeling of DNA with modified or „chromophore“ carrying nucleotides and DNA polymerases used Mühlegger, K.; Angerer, B.; Seela, F.; Ankenbauer, W.; Augustin, M.; Gumbiowski, K.; Zulauf, M. (Roche Diagnostics GmbH, Mannheim, Germany), US-Patent 2004/0214221A1.
18.	2-Azapurine compounds and their use Seela, F.; Rosemeyer, H.; Schweinberger, E.; Heindl, D.; Bergmann, F. (Roche Diagnostics GmbH, Mannheim, Germany), EU-Patent 1 214 331 2002, International Publication Number WO 01/16149 A2 2001.
19.	Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses Seela, F.; Bergmann, F.; von der Eltz, H.; Heindl, D.; Seidel, C.; Becher, G. (Roche Molecular Systems Inc, Alameda, USA), US-Patent 2003, 0 198 982 A1.
20.	Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses Seela, F.; Bergmann, F.; von der Eltz, H.; Heindl, D.; Seidel, C.; Becher, G. (F. Hoffmann-La Roche AG, Basel, Schwitzerland / Roche Diagnostics GmbH, Mannheim, Germany), EU-Patent 1 307 469 2003, International Publication Number WO 02/12263 A1.
21.	Fluoreszierende Nucleoside und Oligonucleotide mit hoher Stabilität Seela, F.; Rosemeyer, H.; Schweinberger, E. (ChemBiotech), DE-Patent 10 2004 009 977 A12004.
22.	5-Aza-7-deazapurine Derivatives for Treating Flaviviridae Gosselin, G; Seela, F.; La Colla, P.; Storer, R.; Dukhan, D.; Leroy, F.0, US-Patent 2006/0040944 A1.